Internal Medicine

Biography

Mohanakrishnan Sathyamoorthy, M.D., FACC

“Dr. Mo” is a board-certified Cardiologist and Professor and founding Chair of the Department of Medicine at the Anne Burnett Marion School of Medicine at TCU. At TCU, he established the Sathyamoorthy Laboratory and currently mentors over twenty-five MD candidate research students, several post-doctoral associates, and undergraduate students from across the country. His group has made several novel discoveries, including making multiple novel genotype to phenotype associations in aneurysmal disorders being further investigated in transgenic animal models, conduct of hypothesis driven population genomic and clinical database studies across a variety of disease states, use of machine learning and artificial intelligence techniques in radiomics and disease state analysis, and novel thrombosis research. He recently received an NIH R01 as a co-investigator and his Lab submitted the first NIH R01 for the Burnett School of Medicine in October of 2025. He is nationally recognized in the field of cardiovascular thrombosis and is frequently invited to lecture on cardiology-related topics both here in the United States and overseas at international meetings. He is a practicing cardiologist and founding president of Consultants in Cardiovascular Medicine and Science in Fort Worth. This comprehensive cardiovascular practice serves patients through personalized clinical care and patient-focused translational research. In 2023, he founded the Fort Worth Institute for Molecular Medicine and Genomics Research to serve as a translational science core laboratory resource for his research efforts and for the Burnett School of Medicine at TCU, where students and faculty can pursue cutting-edge research. He envisions this entity to contribute to the growth of the Fort Worth Medical Innovation District.

A native of Potsdam, NY, Dr. Mo earned his undergraduate and graduate degrees in biomedical and mechanical engineering (biomechanics) at Johns Hopkins University, followed by an M.D. with distinction in research at the State University of New York Stony Brook, where he was honored with the Citizenship Award and Award for Excellence in Research at commencement. During his time at Stony Brook, he was selected as one of 15 students nationally into the on-campus NIH Research Scholars’ program, where he pursued functional immunogenomics research under the mentorship of a prominent cancer immunology investigator and member of the National Academy of Sciences. He was subsequently named a Harrison Society Scholar and trained as a physician-scientist in the ABIM research pathway at Vanderbilt University in Internal Medicine and Cardiovascular Medicine. After serving as Chief Fellow in Cardiovascular Medicine and completing his post- doctoral research fellowship with a prominent thrombosis investigator, he joined the faculty as a physician- scientist after obtaining his first round of NIH funding. He developed a research program that studied the effect of molecular manipulation of fibrinolytic genes on cellular migration, taught the course in anticoagulant, antiplatelet, and fibrinolytic pharmacology in the Vanderbilt School of Medicine, and served as a Harrison (Cardiology) service teaching attending. He and his family moved to Fort Worth in 2009 to get closer to their extended family.

Dr. Sathyamoorthy is a highly-peer recognized and honored physician in North Texas, having been named a US News and Report top physician, Castle Connelly top 1% physician, Best In Texas, nominated to Who’s Who publications, and appearing in all local peer-ranked best physicians lists, including 360 West, Fort Worth Magazine, and Dallas Luxury Lifestyles.

Apart from his roles at the Burnett School of Medicine at TCU and leading his practice, Dr. Sathyamoorthy has served in numerous medical executive leadership roles in Fort Worth. These have included Chief of Staff at Baylor All Saints, founding Medical Director of Cardiology for the Baylor Heart Vascular Hospital in Fort Worth, and board member for the Baylor Scott and White Quality Alliance ACO. He served an extended term as President of the Tarrant County AHA Board, served on the Fort Worth Opera Advisory Board and the Executive Board of Fort Worth Academy. He and his wife, Heather, are committed to supporting the performing arts, enjoy collecting art, love sports, have two teenage children and a whippet terrier (Bo), and are proud to make their home in Fort Worth.

Education & Training

Research Interests

• Familial and disease state genetic and genomic studies derived from clinical observations, principally in aneurysmal, cardiomyopathy and arrhythmia disease states.
• Comparative biologic translational medicine – observing animal adaptations to solve perplexing problems in human diseases.
• Animals studied include Giraffes, Crocodiles, and Bears!
• Hypothesis-driven cardiovascular thrombosis research.
• Characterization of archaeogenetic influence on modern disease states.
• Hypothesis-driven research using population-level genomic databases (UK Biobank and NIH AoU)
• Application of machine learning to patient-centered research from complex clinical data sets (phenomic research)

Professional Societies

• Heart Valve Society 2026-
• Society of Thoracic Surgeons, Associate Member 2025-
• Near Southside, Silver Member 2025-
• Microvascular Network (MVN) 2024-
• American Society of Echocardiography (ASE) 2023-
• Alliance for Academic Internal Medicine (AAIM) 2021-
• Texas Medical Association (TMA) 2020-
• Tarrant County Medical Association (TCMA) 2020-
• American Association for the Advancement of Science (AAAS) 2019-
• American Heart Association (AHA – Local Board), Professional Member since 2023, 2010-
• Gottlieb C. Friesinger Society, Vanderbilt University, Member 2006-
• Brittingham Society, Department of Medicine, Vanderbilt University 2003-
• Tinsley Harrison Society of Physician-Scientists in Medicine, Vanderbilt 2003-
• American College of Cardiology, Fellow since 2008, 2003-

ELECTED MEMBERSHIP IN RESEARCH AND ACADEMIC SOCIETIES

• Member, Association of Professors of Medicine (APM) of AAIM 2025
• Member, Association of Professors of Cardiology (APC) 2025
• Elected Member, Sigma Xi 2024
• Permanent Member, Tinsley Harrison Society of Physician-Scientists in Medicine, 2001